Fig 6. Necrosis and Regeneration.
The plot shows how the spatial extent of the necrotic region evolves according to our model of the effect of CCl4 intoxication along a representative sinusoid of a mouse liver. The representative hepatocytes are separated by vertical black lines in this plot, A color range from white to red indicates zero to full necrotic damage of the respective representative hepatocyte. Necrosis develops during the first day, until a maximally necrotic state is attained. Subsequent regeneration starting on the second day leads to a shrinkage of the necrotic region until the end of day 7.