Fig 10. Caffeine Clearance After CCl₄-Induced Necrosis.

The plot shows the caffeine concentrations in the plasma in the venous blood pool for 24 hours after intravenous bolus injection at different time points during the necrosis development and regeneration process induced by CCl4. The influence of the necrotic damage occurred during day 0, leading to slowest decrease of caffeine concentration in the venous blood for the injection at day 1. Regeneration during days 1 to 7, according to our necrosis model from Fig 6, lead to increasingly faster decrease of the caffeine concentrations for the later injections, until the fully regenerated state was reached for the injection at day 7. The inset shows the second pass after the first recirculation cycle, in this case after 30.2 s. The table lists the half-life of caffeine in the organism, i.e., the first decrease by 50%, if it occurs within one day after the administration. These numbers confirm the observations from the plot which only involves the venous blood pool.