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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Arthritis Rheumatol. 2015 May;67(8):2097–2107. doi: 10.1002/art.39178

Figure 5. Kinases and receptors mediating TTR effects on human chondrocytes.

Figure 5

(A) Representative images of western blotting for phosphorylated MAPK in chondrocytes treated with TTRs. (B) Graph shows the quantification of phosphorylated MAPK in 3 human chondrocyte preparations treated with 4 µM of TTRs for 24 h. Values are the mean and SD as the ratio of TTRs treated cells to vehicle-only treated cells. * = P < 0.05 versus Control. (C) Chondrocytes co-treated with 4 µM of V122I and antibody to RAGE, CLI95, SB203580 and PD98059 for 24 h. Graph shows the changes in gene expression of 3 donors. Values are the mean and SD. *P < 0.05 versus V122I TTR.