Table 5.
COX-2 Haploblock Comprised of Four SNPs.
| rs2206593 | rs5275 | rs5277 | rs2383515 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D' | R^2 | p-value | D' | R^2 | p-value | D' | R^2 | p-value | D' | R^2 | p-value | |
| rs2206593 | 1.00 | 1.00 | 0.0000 | |||||||||
| rs5275 | 0.99 | 0.02 | 0.0985 | 1.00 | 1.00 | 0.0000 | ||||||
| rs5277 | 0.99 | 0.01 | 0.2739 | 1.00 | 0.09 | 0.0007 | 1.00 | 1.00 | 0.0000 | |||
| rs2383515 | 0.99 | 0.01 | 0.1665 | 0.89 | 0.39 | 0.0000 | 1.00 | 0.04 | 0.0044 | 1.00 | 1.00 | 0.0000 |
The Four Cox-2 SNPs genotyped in this study were tested to determine the likelihood they were inherited together by calculating the normalized linkage disequilibrium statistic (D’) and the square of the correlation coefficient between each SNP (R2). D’ and R2 lie in the range from 0 to 1, with 1 indicating the strongest possible linkage disequilibrium/correlation.