Table 2. The Association of Reproductive Hormones with Innate Antiviral Activity.
Group | Number | HSV-1 Suppression vs. Control (%) | HSV-2 Suppression vs. Control (%) | HIV-1 Suppression vs. Control (%) | Ratio of CVL Protein Content (Premenopausal: Postmenopausal) |
---|---|---|---|---|---|
Postmenopausal | 29 | 23.22 ± 15.46 | 36.56 ± 29.36 | 10.96 ± 29.41* | 1 |
Days 1-14 | 26 | 31.20 ± 15.91 | 40.23 ± 31.50 | 39.29 ± 40.57 | 2.2 |
Days 15-28 | 27 | 30.21 ± 29.38 | 39.26 ± 36.85 | 26.49 ± 38.45 | 2.6 |
OCP | 27 | 28.09 ± 21.18 | 52.86 ± 24.42 | 35.77 ± 31.72 | 2.7 |
DMPA | 28 | 31.95 ± 22.03 | 38.25 ± 41.61 | 32.95 ± 35.00 | 1.8 |
LNG-IUD | 28 | 25.09 ± 26.34 | 48.18 ± 30.55 | 37.88 ± 37.22 | 3.1 |
P-Value** | 0.63 | 0.38 | 0.04*** | <0.001 |
One postmenopausal result outlier excluded.
P-value from one way analysis of variance
HIV-1 suppression was lower among postmenopausal women compared to reproductive-aged women (11% vs. 34%, respectively; P=0.002)