Skip to main content
. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Gene. 2015 Jun 26;570(1):25–35. doi: 10.1016/j.gene.2015.06.062

Figure 2. Scheme of signaling pathways involving EFS and CASS4 proteins.

Figure 2

Integrin (αβ) heterodimer activation at focal adhesions triggers phosphorylation of CAS proteins by FAK and SRC, allowing them to act as scaffolds for CRK and downstream factors that reorganize the actin cytoskeleton, and influence proliferation and survival signaling. Dotted lines stand for phosphorylation events, solid lines stand for direct interactions between proteins.