Table 1.

Sixteen putative cis-eQTL SNPs for OPRM1 in the BrainCloud cohort and tested for association with heroin addiction in European American and African American cases from the Urban Health Study (UHS) vs. population controls. SNPs are sorted by the meta-analysis P value for association with heroin addiction, with statistically significant results shown in bold (meta-analysis P<0.005).

SNP (Minor Allele)	Base Pair Position (NCBI build 36)	SNP Type (Distance to OPRM 1 for intergenic SNPs)	Association with OPRM1 expression in BrainCloud		Association with OPRM1 expression in BrainCloud	Association with heroin addiction
						African Americans (N=1,293 cases and 2,369 controls)			European Americans (N=711 cases and 6,384 controls)			Meta analysis P
			P, over all	P, European Americans only (N=110)	P, Africa Americans only (N=114)	MAF	P	OR (95% CI)	MAF	P	OR (95% CI)
rs9478495 (A)	154,365,602	intergenic (−36,533)	0.22	0.89	0.015	0.22	0.019	1.16 (1.02-1.30)	0.16	0.0017	1.27 (1.09-1.47)	8.9×10−5
rs3778150 (C)	154,425,351	intronic	0.089	0.042	0.38	0.19	0.037	1.15 (1.01-1.30)	0.16	0.0012	1.28 (1.10-1.47)	1.2×10−4
rs9384169 (C)	154,354,864	intergenic (−47,271)	0.25	0.90	0.046	0.31	0.029	1.12 (1.01-1.25)	0.32	0.025	1.15 (1.02-1.30)	2.0×10−3
rs562859 (C)	154,456,266	synonymous	0.054	0.016	0.96	0.38	0.018	1.13 (1.02-1.25)	0.33	0.070	1.12 (0.99-1.26)	4.3×10−3
rs613355 (C)	154,491,542	intronic	0.010	0.012	0.72	0.39	0.071	1.10 (0.99-1.22)	0.34	0.067	1.12 (0.99-1.26)	0.011
rs13203628 (G)	154,502,815	intronic	0.037	0.010	0.82	0.34	0.068	1.11 (0.99-1.23)	0.26	0.11	1.11 (0.97-1.28)	0.019
rs671531 (A)	154,482,434	intronic	0.015	0.010	0.92	0.39	0.11	1.08 (0.98-1.20)	0.33	0.079	1.11 (0.99-1.26)	0.019
rs9479779 (G)	154,544,688	intronic	0.30	0.57	0.042	0.085	0.57	1.05 (0.88-1.25)	0.059	0.20	0.84 (0.65-1.10)	0.48
rs558948 (T)	154,483,556	intronic	0.0017	0.00094	0.71	0.16	0.76	1.02 (0.89-1.16)	0.25	0.58	1.04 (0.91-1.19)	0.53
rs650825 (A)	154,470,229	intronic	0.0034	0.0017	0.45	0.17	0.86	0.99 (0.87-1.12)	0.25	0.57	1.04 (0.91-1.19)	0.72
rs10485060 (A)	154,557,793	intronic	0.039	0.34	0.24	0.022	0.23	0.81 (0.57-1.15)	0.047	0.66	1.06 (0.81-1.39)	0.73
rs647192 (G)	154,464,437	intronic	0.0085	0.0018	0.63	0.085	0.80	0.98 (0.82-1.17)	0.25	0.60	1.04 (0.91-1.18)	0.78
rs647303 (C)	154,324,902	intergenic (−77,233)	0.79	0.28	0.0010	0.11	0.29	1.09 (0.93-1.27)	0.26	0.60	0.97 (0.85-1.10)	0.85
rs6900805 (G)	154,329,725	intergenic (−72,410)	0.79	0.28	0.0010	0.11	0.34	1.08 (0.92-1.26)	0.26	0.63	0.97 (0.85-1.10)	0.87
rs538174 (C)	154,494,229	intronic	0.012	0.0028	1.00	0.076	0.27	0.89 (0.74-1.09)	0.24	0.35	1.06 (0.93-1.22)	0.91
rs1852629 (T)	154,564,432	intronic	0.044	0.090	0.38	0.42	0.96	1.00 (0.90-1.10)	0.43	0.87	1.01 (0.90-1.13)	0.92

MAF, minor allele frequency; OR, odds ratio; CI, confidence interval