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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Biol Psychiatry. 2015 Jan 29;78(7):474–484. doi: 10.1016/j.biopsych.2015.01.003

Table 2.

Haplotype analyses of rs3778150 and the widely-studied missense SNP rs1799971 across all study cohorts and ancestry groups. The single SNP analyses suggested that the rs3778150 minor allele (C) and rs1799971 major allele (A) conferred increased risks for heroin addiction.

rs3778150 allele rs1799971 allele Urban Health Study, European Americans (N=7,095) Urban Health Study, African Americans (N=3,662) CIDR – Gelernter Study, African Americans (N=852) Australian Heroin Dependence Study, Australians of European ancestry (N=5,120)
Freq P OR (95% CI) Freq P OR (95% CI) Freq P OR (95% CI) Freq P OR (95% CI)
C A 0.16 0.0070 1.29 (1.07-1.55) 0.19 0.0056 1.24 (1.06-1.44) 0.18 0.40 1.17 (0.82-1.66) 0.17 0.0045 1.26 (1.07-1.47) 1.5×10−6
T A 0.70 0.10 0.79 (0.60-1.05) 0.79 0.13 1.32 (0.92-1.87) 0.79 0.81 0.91 (0.41-2.01) 0.71 0.80 1.02 (0.89-1.16) 0.79
T G 0.13 - ref. 0.03 - ref. 0.02 - ref. 0.12 - ref. -