Table 5.
Allele and genotype frequencies of APE1 rs1130409 (Asp148Glu) in central Saudi Arabia and other populations.
| Population | Genotype freq. (number) | Allele frequency | Pairwise χ 2 test value between CRS & other populations | p value | |||
|---|---|---|---|---|---|---|---|
| Asp/Asp freq. (number) | Asp/Glu freq. (number) | Glu/Glu freq. (number) | Wild type Asp |
Variant Glu |
|||
| CEU (n = 226) | 0.319 | 0.407 | 0.274 | 0.52 | 0.48 | 0.13 | 0.71 |
| CHB (n = 84) | 0.214 | 0.476 | 0.310 | 0.45 | 0.55 | 0.41 | 0.51 |
| JPT (n = 170) | 0.094 | 0.494 | 0.412 | 0.34 | 0.66 | 6.61 | 0.01 |
| GIH (n = 176) | 0.114 | 0.341 | 0.545 | 0.28 | 0.72 | 12.86 | 0.0003∗ |
| YRI (n = 226) | 0.133 | 0.381 | 0.487 | 0.32 | 0.68 | 9.24 | 0.002∗ |
| MKK (n = 286) | 0.098 | 0.524 | 0.378 | 0.36 | 0.64 | 6.05 | 0.01 |
| TSI (n = 174) | 0.230 | 0.448 | 0.322 | 0.45 | 0.55 | 0.53 | 0.46 |
| CRS (n = 100) | 0.27 | 0.46 | 0.27 | 0.50 | 0.50 | Ref | — |
Population descriptions:
CEU: Utah residents with Northern and Western European ancestry from the CEPH collection.
CHB: Han Chinese in Beijing, China.
JPT: Japanese in Tokyo, Japan.
GIH: Gujarati Indians in Houston, Texas.
YRI: Yoruba in Ibadan, Nigeria.
MKK: Maasai in Kinyawa, Kenya.
TSI: Toscans in Italy.
CRS: Saudi population residing in Riyadh region of central Saudi Arabia.
∗ p values significant after Bonferroni correction.