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REM sleep plotted as 20 h totals for baseline (Base), handling control (HC) and for days on which the mice received ICV injections of saline (SAL), corticotropin releasing factor (CRF) or astressin (AST) prior to signaled, escapable shock (SES) or to signaled, inescapable shock (SIS) training. (A) Total REM; (B) REM % (total REM/total sleep time × 100%); (C) REM episodes; (D) average REM episode duration. Comparisons of SES (n = 9) and SIS (n = 9): *p < 0.05. Values are means ± SEM.
