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Morphologic aspects of anaplastic large cell lymphoma-anaplastic lymphoma kinase (ALK) positive. (A) Diffuse proliferation of large, highly atypical cells, with prominent pleomorphism (H&E-stained section). Some hallmark cells can be observed; they present large multilobulated ‘horseshoe-like’ nuclei. Neoplastic cells show diffuse expression of (B) CD30; (C) CD43; (D) epithelial membrane antigens and (E) ALK-1. In this case, ALK-1 positivity present exclusive cytoplasmic pattern.
