TABLE 2.
Concentrations of IL-2, IFN-γ, TNF-α, IL-6, and IL-17A among donors with acute pulmonary coccidioidomycosis, the pulmonary sequelae of nodules and cavities, and nonmeningeal disseminated coccidioidomycosis and healthy coccidioidal immune and nonimmune donors
| Group (no. of subjects) | Concn, pg/ml (IQRa) |
||||
|---|---|---|---|---|---|
| IL-2 | IFN-γ | TNF-α | IL-6 | IL-17A | |
| Acute pulmonary coccidioidomycosis (n =16) | 1,559 (468–2,650)b | 518 (0–1,037)b | 33 (0–111)b | 1,485 (0–4,689)b | 14.7 (9.1–20.6)b,c |
| Pulmonary sequelae (n = 9) | 845 (510–1,198)b | 248 (99–398)b | 17 (0–150)b | 1,485 (486–2,485)b | 3.8 (0–11.4)b,c |
| Disseminated coccidioidomycosis (n = 18) | 541 (0–1,470)b | 173 (0–609)b | 341 (0–875)b | 4,584 (0–9,775)b,c | 6.9 (3.8–10.0)b,c |
| Immune (n = 6) | 315 (52–579)b | 194 (55–334)b | 41 (0–124)b | 691 (313–1,069)b | 0.8 (0.3–1.3) |
| Nonimmune (n = 6) | 0.0 (0–3.1) | 4.4 (0–9.5) | 0.0 (0) | 54 (17–92) | 0.0 (0–0.3) |
a
IQR, interquartile range.
b
P < 0.05 compared to healthy, nonimmune donors.
c
P < 0.01 compared to healthy, immune donors.