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Structural view of the C (A=M) and C/Y (A>M) epitopes. The C/Y (A>M) epitope is composed of ≥5 α-1,2-linked d-Rha4NFo residues (yellow circle). The C (A=M) epitope is composed of the disaccharide d-Rha4NFo (1,3) linked to α-1,2-linked d-Rha4NFo residues on each side (blue circle). All linkages are α-1,2 except the α-1,3 linkage indicated by the black arrows. +++, +, and − correspond to reactivity with MAbs.
