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. 2015 Jul 30;5:12633. doi: 10.1038/srep12633

Figure 2. Impaired production of IL-10 and IL-35 by Treg cells in MLDSTZ induced T1D.

Figure 2

(A) Concentrations of IL-10 and (B) IL-35 in supernatants of stimulated CD4+CD25+ Treg cells sorted from thymic glands, PDLNS and spleen of vehicle or MLDSTZ treated mice. (C) Representative histograms showing the expression of IL-12p35 (left panels) or Ebi3 (right panels) in CD4+CD25+Foxp3+ Treg or CD4+CD25− Th cells in thymocytes, PDLNs cells and splenocytes of vehicle or MLDSTZ injected mice on indicated days. Results are expressed as means ± SEM, from two experiments (n = 3 mice/group/experiment). Unpaired t-tests were performed for comparisons between vehicle and MLDSTZ treated groups on corresponding days. *, ** and *** denote p < 0.05, p < 0.01, and p < 0.001, respectively.