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. 2015 Jul 30;5:12548. doi: 10.1038/srep12548

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(A) Expression profile of K2P channels in F-11 cells. PCR-primers specific for transcripts of mouse and rat (as indicated) were used to cover the hybrid genome of F-11 cells. Note that TRESK channels are not expressed. (B) Untransfected F-11 cells displayed typical voltage-gated potassium and sodium channels in ramp recordings and in depolarising step recordings (inset, left panel) whereas TRESK transfected F-11 cells displayed a shift of reversal potential to more negative values in ramp recordings and large outward currents upon depolarising steps (inset, right panel). (C) Current injection (40 pA) leads to a single action potential in non-transfected F-11 cells (left panel) whereas even high amplitude current injection (340 pA) failed to elicit an action potential in TRESK-transfected cells (right panel). Insets display current steps from −60 to 300 pA.