Fig. 3.

(a) Side-view of tissue-mimicking phantom with wire inclusions and short-axis outline of transducer provided overhead; purple circles represent location of wires, while blue-white circle denotes location of interstitial fiber; dashed gray lines depict propagation of acoustic waves; external and interstitial irradiation volumes are denoted in red; d_p is distance traveled by photons for external irradiation, while d_a is distance traveled by acoustic wave for both irradiation types. (b) Top-view of phantom; transducer footprint is depicted by black dashed line; blue line represents side-fire imaging fiber location. (c) Top-view of prostate sample; green ellipse represents area of AuNS injection, while white ellipse denotes control region. (d) Side-view of prostate sample. (e) Stack of liver sections cast in pure gelatin for deep interstitial laser delivery; irradiation fiber (blue arrow) and wire imaging target (white arrow) are visible at bottom of image. (f) Liver sample for PA spectroscopy by interstitial laser irradiation; black lines indicate approximate US imaging volume.