Table 2.
Inhibitor titer elevations detected at enrollment and during the study according to selected demographic and clinical characteristics.
| Detected at Enrollment | Detected During Study Follow-up | Total Detected | |
|---|---|---|---|
| Non-Severe | 3/9 (33%) | 5/14 (36%) | 8/23 (35%) |
| Age >5 years | 4/9 (44%) | 6/14 (43%) | 10/23 (43%) |
| Exposure Days >150 | 3/9 (33%) | 2/14 (14%) | 5/23 (22%) |
| Exposure Days>20 | 8/9 (89%) | 5/14 (36%) | 13/23 (57%) |
| White Non-Hispanic Ethnicity | 7/9 (78%) | 10/14 (71%) | 17/23 (74%) |
| High Risk Mutation | 8/9 (89%) | 10/14 (71%) | 18/23 (78%) |
| Initial Titer >1.0 NBU | 4/9 (44%) | 11/14 (79%) | 15/23 (65%) |
| Peak Titer >1.0 NBU | 4/9 (44%) | 11/14 (79%) | 15/23 (65%) |
| Peak Titer >5.0 NBU | 2/9 (22%) | 5/14 (36%) | 7/23 (30%) |
| No Clinical Indication | 9/9 (100%) | 5/14 (36%) | 14/23 (61%) |
NBU = Nijmegen Bethesda Units