Table 3.1.

Primary and Secondary Receptors for Common AAV Serotypes

Serotype	Primary Receptor	Secondary Receptor(s)
AAV1	N-linked α2,3-/α2,6-Sialic acid (Ng et al., 2010; Wu, Miller, Agbandje-McKenna, & Samulski, 2006)	Unknown
AAV2	Heparan sulfate (Summerford & Samulski, 1998)	Integrins αVβ5/α5β1, FGFR1 (fibroblast growth factor receptor 1) (Qing et al., 1999), HGFR (hepatocyte growth factor receptor) (Qing et al., 1999), and laminin receptor (Akache et al., 2006)
AAV3	Heparan sulfate (Rabinowitz et al., 2002)	FGFR1 (Blackburn, Steadman, & Johnson, 2006), HGFR (Ling et al., 2010), laminin receptor (Akache et al., 2006)
AAV4	O-linked α2,3-Sialic acid (Kaludov et al., 2001)	Unknown
AAV5	N-linked α2,3-Sialic acid (Kaludov et al., 2001; Walters et al., 2001)	PDGFR (platelet-derived growth factor receptor) (Di Pasquale et al., 2003)
AAV6	N-linked α2,3-/α2,6-Sialic acid (Wu, Miller, et al., 2006), heparan sulfate (Ng et al., 2010)	EGFR (epidermal growth factor receptor) (Weller et al., 2010)
AAV7	Unknown	Unknown
AAV8	Unknown	Laminin receptor (Akache et al., 2006)
AAV9	N-linked β1,4-Galactose (Shen, Bryant, Brown, Randell, & Asokan, 2011)	Laminin receptor (Akache et al., 2006)