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. Author manuscript; available in PMC: 2015 Jul 30.
Published in final edited form as: Adv Genet. 2014;87:125–197. doi: 10.1016/B978-0-12-800149-3.00003-2

Table 3.2.

Heterologous Envelope Proteins Used for Psuedotyping Lentiviral Vector for CNS Applications

Envelope Host Range Cell Type Stability upon Concentration
VSV-G Mouse, rat, pig, dog, human Ubiquitous The most established protocol; stable, suitable for concentration
LCMV Mouse, rat Strong preference to astrocytes, glioma cells; neurons to a lesser degree Stable, suitable for concentration
MV Mouse, rat Ubiquitous Stable, suitable for concentration
Rabies-G Mouse, rat Preference to neurons; excellent axonal transport Stable, suitable for concentration
MoMLV Mouse, rat Similar pattern to LCMV; capable of infecting neurons Stable, suitable for concentration
RRV-G Mouse, rat, human cells in vitro Glial cells and neurons Stable, suitable for concentration

Vesicular stomatitis virus G-protein (VSV-G); lymphocytic choriomeningitis virus protein (LCMV); Mokola virus G-protein (MV); Rabies virus G-protein (Rabies-G); murine leukemia virus envelope protein (MoMLV); Ross River virus G-protein (RRV-G).