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. Author manuscript; available in PMC: 2015 Jul 30.
Published in final edited form as: Adv Genet. 2014;87:125–197. doi: 10.1016/B978-0-12-800149-3.00003-2

Table 3.3.

Typical Promoter Types Used to Drive Expression in Lentiviral Vectors in the CNS

Promoter Strength Cell Type
CMV Strong but subject to transcriptional silencing over time Ubiquitous
PGK Strong Ubiquitous
EF1-α Strong Ubiquitous
TRE Strong, inducible by ttA or ttS+/−Dox, respectively Ubiquitous
GFAP Moderate-strong Astrocytes
CaMKII Strong Postnatal neurons (strong after week 4–5 in mice and rats)
Synapsin I Moderate-strong Developing neurons (weaker after week 4–5 in mice and rats)
Thy-1,2 Moderate-strong Prenatal and postnatal neurons

Cytomegalovirus (CMV); phosphoglycerate kinase 1 promoter, (PGK); Human elongation factor-1 alpha promoter, (EF1-α); The tetracycline response element-containing promoter, (TRE); Glial fibrillary acidic protein promoter, (GFAP); α-calcium/calmodulin-dependent protein kinase II, (CaMKII); Synapsin type I promoters, (Synapsin I); thymocyte differentiation antigen 1 and 2 promoter, (Thy-1,2).