Table 3.4.

Representative Promoters for CNS Gene Transfer

Promoter	Specificity	Strength	Ref
Viral (CMV-IE, RSV-LTR, MoMLV-LTR, SV40)	Ubiquitous	+++	(Papadakis, Nicklin, Baker, & White, 2004)
Eukaryotic (EF1-α)	Ubiquitous	++++	(Xu et al., 2001)
Ubiquitin C	Ubiquitous	+	(Qin et al., 2010)
GUSB	Ubiquitous	+	(Husain, Passini, Parente, Fraser, & Wolfe, 2009)
PPE	All of CNS	+++	(Xu et al., 2001)
SYN1	Neurons	++	(Kugler et al., 2001)
NSE	Neurons	++++	(Smith-Arica et al., 2000)
GFAP	Astrocytes	+++	(Lee, Messing, Su, & Brenner, 2008; Smith- Arica et al., 2000)
MBP	Oligodendrocytes	++	(Gow, Friedrich, & Lazzarini, 1992)
F4/80	Microglia	++	(Cucchiarini, Ren, Perides, & Terwilliger, 2003)
MCH	MCH neurons	++	(van den Pol, Acuna- Goycolea, Clark, & Ghosh, 2004)
MeCP2 (MeP229)	Neurons	+	(Gray, Foti, et al., 2011)

CMV, cytomegalovirus; RSV-LTR, Rous sarcoma virus long terminal repeat; SV40, simian virus 40; EF1-α, Human elongation factor-1 alpha promoter; PPE, preproenkephalin; GFAP, Glial fibrillary acidic protein.