Table 1.
Characteristics of eligible studies included in the meta-analysis.
| Author | Year | Country | Ethnicity | Disease | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Quality Score | Sample Size (Case/Control) | GG (Case/Control) | GC (Case/Control) | CC (Case/Control) | HWE of Control |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chen et al. | 2013 | China | Asian | CAD | Taqman | 1:1.79/1:1.184 | 64.57 ± 10.33/ 64.08 ± 11.21 | 14 | 658/658 | 181/194 | 305/330 | 172/134 | 0.769 |
| Hamann et al. | 2014 | German | Caucasian | CAD | HRM | Unavailable | Unavailable | 12 | 206/200 | 120/117 | 74/73 | 12/10 | 0.748 |
| Ramkaran et al. | 2014 | South Africa | Indian | CAD | PCR-RFLP | 1:0/1:0 | 37.6 ± 0.40/ 37.5 ± 0.44 | 12 | 106/100 | 50/45 | 43/46 | 13/9 | 0.569 |
| Xiong et al. | 2014 | Chian | Asian | CAD | PCR-RFLP | 1:0.661/1:0.601 | 65.13 ± 11.86/ 62.59 ± 12.89 | 11 | 295/283 | 41/61 | 141/125 | 113/97 | 0.086 |
| Huang et al. | 2015 | China | Asian | IS | Taqman | 1:0.616/1:0.616 | 61.0 (54, 68)/ 63.0 (54, 70) | 14 | 531/531 | 81/55 | 261/257 | 189/219 | 0.106 |
| Jeon et al. | 2013 | Korea | Korean | IS | Taqman | 1:0.441/1:0.496 | 64.16 ± 11.90/ 63.14 ± 10.19 | 15 | 678/553 | 128/76 | 327/266 | 223/211 | 0.589 |
| Liu et al. | 2013 | China | Asian | IS | PCR-RFLP | 1:0.608/1:0.581 | 67.52 ± 10.29/ 66.34 ± 11.07 | 12 | 296/391 | 52/77 | 159/198 | 85/116 | 0.65 |
| Zhu et al. | 2014 | China | Asian | IS | PCR-LDR | 1:0.688/1:0.685 | 61.62 ± 0.986/ 62.05 ± 0.982 | 12 | 368/381 | 50/64 | 173/185 | 145/132 | 0.952 |
HWE: Hardy-Weinberg equilibrium; CAD: Coronary Artery Disease; HRM: High-resolution melting; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; IS: ischemic stroke.