Table 2.

Pooled ORs and 95% CIs of the association between miR-146a (rs2910164) and coronary artery disease (CAD) and ischemic stroke (IS).

Genetic Model	Overall or Subgroup	CAD				IS
		n	OR (95% CI)	p-Value	I2 (%)	n	OR (95% CI)	p-Value	I2 (%)
G vs. C	Overall	5	0.86 (0.77, 0.96)	0.01	0%	4	1.07 (0.89, 1.29)	0.45	74%
	Large size	2	0.86 (0.73, 1.00)	0.05	NA	2	1.25 (1.11, 1.41)	0.0003	0%
	Small size	3	0.87 (0.73, 1.03)	0.10	0%	2	0.91 (0.78, 1.05)	0.20	0%
	Chinese	2	0.83 (0.73, 0.95)	0.006	0%	3	1.02 (0.80, 1.29)	0.89	76%
	Other (Caucasian, Indian, Korean)	2	0.97 (0.75, 0.83)	0.83	0%	1	1.24 (1.06, 1.46)	0.009	NA
GG vs. CC	Overall	4	0.70 (0.55, 0.88)	0.003	0%	4	1.17 (0.78, 1.77)	0.44	76%
	Large size	1	0.73 (0.54, 0.98)	0.04	NA	2	1.64 (1.27, 2.12)	0.0002	0%
	Small size	3	0.65 (0.44, 0.96)	0.03	0%	2	0.81 (0.59, 1.10)	0.18	0%
	Chinese	2	0.68 (0.53, 0.88)	0.003	0%	3	1.05 (0.62, 1.77)	0.87	78%
	Other (Caucasian, Indian, Korean)	2	0.81 (0.43, 1.54)	0.53	0%	1	1.59 (1.13, 2.24)	0.007	NA
GC vs. CC	Overall	4	0.80 (0.65, 0.98)	0.03	0%	4	1.08 (0.94, 1.25)	0.27	0%
	Large size	1	0.72 (0.55, 1.39)	0.02	NA	2	1.17 (0.98, 1.40)	0.09	0%
	Small size	3	0.91 (0.66, 1.25)	0.56	0%	2	0.95 (0.75, 1.22)	0.71	10%
	Chinese	2	0.80 (0.64, 1.00)	0.05	39%	3	1.04 (0.86, 1.27)	0.67	20%
	Other (Caucasian, Indian, Korean)	2	0.74 (0.39, 1.43)	0.37	0%	1	1.16 (0.91, 1.49)	0.23	NA
GG/GC vs. CC	Overall	4	0.76 (0.63, 0.93)	0.007	0%	4	1.10 (0.90, 1.34)	0.36	54%
	Large size	1	0.72 (0.56, 0.93)	0.01	NA	2	1.26 (1.07, 1.50)	0.007	0%
	Small size	3	0.83 (0.61, 1.11)	0.21	0%	2	0.91 (0.73, 1.14)	0.41	17%
	Chinese	2	0.76 (0.62, 0.94)	0.01	0%	3	1.04 (0.79, 1.35)	0.79	60%
	Other (Caucasian, Indian, Korean)	2	0.78 (0.42, 1.45)	0.43	0%	1	1.26 (1.00, 1.59)	0.05	NA