Table 3.
Stratified effects of miR-146a (rs2910164) on ischemic stroke risk under dominant genetic model (GG/GC vs. CC).
| Selected Variables | Number of Studies | OR (95% CI) | p-Value | I2 (%) | |
|---|---|---|---|---|---|
| TOAST | LAA | 3 | 0.80 (0.51, 1.27) | 0.34 | 71% |
| SVD | 3 | 1.29 (0.90, 1.84) | 0.17 | 58% | |
| Gender | Male | 2 | 1.06 (0.82, 1.38) | 0.65 | 0% |
| Female | 2 | 1.16 (0.45, 2.97) | 0.76 | 86% | |
| Smoker | Yes | 2 | 1.36 (0.91, 2.03) | 0.14 | 0% |
| No | 2 | 1.09 (0.86, 1.38 ) | 0.86 | 69% | |
| Hypertension | Yes | 2 | 0.87 (0.42, 1.82) | 0.72 | 78% |
| No | 2 | 1.30 (0.97, 1.75) | 0.08 | 0% | |
| Diabetes mellitus | Yes | 2 | 1.76 (0.96, 3.21) | 0.07 | 0% |
| No | 2 | 1.25 (0.95, 1.63) | 0.11 | 0% | |
| Hyperlipidemia | Yes | 2 | 1.16 (0.78, 1.71) | 0.47 | 17% |
| No | 2 | 1.23 (0.80, 1.88) | 0.34 | 42% | |
TOAST: Trial of Org 10172 in Acute Stroke Treatment; LAA, Large artery atherosclerosis; SVD, Small vessel Disease.