Figure 3.

Summary of intracellular translocation directions of selected key proteins involved in transcriptional regulation, cell cycle control and transmission of cell surface signals revealed to be important for differentiation of immature oligodendroglial cells. (1) Nuclear import of Notch intracellular domain (NICD) was shown to have a different impact on the differentiation process depending on the nature of Notch ligands (Jagged1, F3/contactin); (2) The Mash1 protein is not exported from the nucleus; however, its inhibitory binding partner p57kip2 is actively translocated during the differentiation process thereby allowing Mash1 dependent transactivation of target genes to occur.