Table 1.
Molecules | Major Function in OPCs | Role in MS/MS-Models | References |
---|---|---|---|
CDK5 | migration, differentiation and myelination, mRNA transport | – | Miyamoto et al., 2007/2008 [59,60]; Yang et al., 2013 [57]; Zhou et al., 2015 [56] |
CDK2 | cell cycle progression | LPC: alters adult OPCs renewal, differentiation, remyelination | Malumbres et al., 2005 [53]; Caillava et al., 2011 [49]; Göttle et al., 2015 [55] |
E2F1 | modulates chromatin components during transition from proliferation to differentiation | – | Magri et al., 2014 [65] |
p21cip1 | proliferation, differentiation | – | Ghiani et al., 1999 [50] |
p53 | proliferation, differentiation | MS lesions: apoptosis | Eizenberg et al., 1996 [77]; Wosik et al., 2003 [80] |
p27kip1 | proliferation | LPC: proliferative response | Crockett et al., 2005 [76]; Raff et al., 2007 [70]; Durand et al., 1997/1998 [71,74]; Miskimis et al., 2002 [72]; Tamaki et al., 2004 [73] |
p57kip2 | glial fate decision, differentiation | MS lesions: myelin repair | Kremer et al., 2009 [85]; Jadasz et al., 2012 [84]; Pfeifenbring et al., 2013 [90]; Göttle et al., 2015 [55] |
Abbreviations: lysolecithin (LPC), oligodendroglial precursor cells (OPCs), Multiple Sclerosis (MS).