Table 1.

Cell cycle-associated key molecules.

Molecules	Major Function in OPCs	Role in MS/MS-Models	References
CDK5	migration, differentiation and myelination, mRNA transport	–	Miyamoto et al., 2007/2008 [59,60]; Yang et al., 2013 [57]; Zhou et al., 2015 [56]
CDK2	cell cycle progression	LPC: alters adult OPCs renewal, differentiation, remyelination	Malumbres et al., 2005 [53]; Caillava et al., 2011 [49]; Göttle et al., 2015 [55]
E2F1	modulates chromatin components during transition from proliferation to differentiation	–	Magri et al., 2014 [65]
p21cip1	proliferation, differentiation	–	Ghiani et al., 1999 [50]
p53	proliferation, differentiation	MS lesions: apoptosis	Eizenberg et al., 1996 [77]; Wosik et al., 2003 [80]
p27kip1	proliferation	LPC: proliferative response	Crockett et al., 2005 [76]; Raff et al., 2007 [70]; Durand et al., 1997/1998 [71,74]; Miskimis et al., 2002 [72]; Tamaki et al., 2004 [73]
p57kip2	glial fate decision, differentiation	MS lesions: myelin repair	Kremer et al., 2009 [85]; Jadasz et al., 2012 [84]; Pfeifenbring et al., 2013 [90]; Göttle et al., 2015 [55]

Abbreviations: lysolecithin (LPC), oligodendroglial precursor cells (OPCs), Multiple Sclerosis (MS).