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Inhibition of eIF2α dephosphorylation by salubrinal. During ER stress, the double-stranded RNA-activated protein kinase-like ER kinase (PERK) phosphorylates the eukaryotic translation initiation factor 2 alpha (eIF2α). Salubrinal prevents eIF2α dephosphorylation by inhibiting the protein complex GADD34/PP1, which consists of the general cellular serine/threonine protein phosphatase 1 (PP1) and the non-enzymatic cofactor growth arrest and DNA damage gene 34 (GADD34).
