Table 4.
A subset of candidate Vibrio splendidus-resistant and susceptibility genes that are involved in the immune signaling pathway.
| Coding Number | Contig ID | Gene Name | Predict Function | Regulation | Log2 FC | Accession Number in Nr Database | Identities (%) |
|---|---|---|---|---|---|---|---|
| Chemokine signaling pathway | |||||||
| A1 | comp76725_c0_seq6 | FOXO1-like | Fork head box protein (Strongylocentrotus purpuratus) | Down | −2.23 | XP_790591.3 | 78 |
| A2 | comp78415_c0_seq14 | ADCY2-like | Adenylatecyclase type 2 (Strongylocentrotus purpuratus) | Down | −5.91 | XP_780688.3 | 72 |
| A3 | comp79708_c0_seq1 | STAT5B-like | Signal transducer and activator of transcription 5B (Strongylocentrotus purpuratus) | Down | −3.81 | XP_003723422.1 | 70 |
| S1 | comp79328_c1_seq13 | NFKB-like | Nuclear factor NF-κB p105 subunit (Apostichopus japonicus) | Up | 1.8 | AEP33644.1 | 68 |
| S2 | comp74502_c1_seq4 | ADCY2-like | Adenylatecyclase type 2-like (Strongylocentrotus purpuratus) | Up | 4.18 | XP_780688.3 | 75 |
| Lysosome | |||||||
| A4 | comp74062_c0_seq5 | NEU1-like | Sialidase-1 (Strongylocentrotus purpuratus) | Down | −1.88 | DAA35227.1 | 85 |
| A5 | com78701_c0_seq2 | AP-1-like | AP-1 complex subunit mu-1-like (Strongylocentrotus purpuratus) | Down | −2.67 | XP_789616.3 | 77 |
| S3 | comp78293_c0_seq2 | ABCA2-like | ATP-binding cassette sub-family A member 2-like (Cricetulus griseus) | Up | 2.49 | XP_003514719.1 | 70 |
| S4 | comp78293_c0_seq4 | ABCA2-like | ATP-binding cassette sub-family A member 2-like (Cricetulus griseus) | Up | 2.49 | XP_003514719.1 | 70 |
| S5 | comp79570_c0_seq6 | SGSH-like | N-sulphoglucosamine sulphohydrolase-like (Strongylocentrotus purpuratus) | Up | 1.01 | XP_794467.1 | 70 |
| S6 | comp77223_c0_seq3 | ABCA2-like | ATP-binding cassette sub-family A member 2, partial (Strongylocentrotus purpuratus) | Up | 1.77 | XP_798273.3 | 68 |
| S7 | comp80153_c0_seq15 | AP-3-like | Adaptor-related protein complex 3, δ 1 subunit-like (Strongylocentrotus purpuratus) | Up | 1.79 | XP_002733668.1 | 69 |
| S8 | comp78750_c3_seq11 | DNase-II like | Plancitoxin-1 (Capitella teleta) | Up | 1.89 | ELU06802.1 | 75 |
| Endocytosis | |||||||
| A6 | comp76401_c0_seq2 | VPS37-like | ESCRT-I complex subunit VPS37 (Nematostella vectensis) | Down | −3.6 | XP_001624048.1 | 82 |
| S9 | comp77471_c1_seq34 | rabaptin5-like | RabGTPase -binding effector protein 1-like (Strongylocentrotus purpuratus) | Up | 1.8 | XP_789966.3 | 77 |
| S10 | comp80156_c1_seq5 | AP-2-like | AP-2 complex subunit alpha-2 (Rattus norvegicus) | Up | 1.16 | NP_112270.2 | 74 |
| S11 | comp77877_c0_seq1 | CHMP5-like | Charged multivesicular body protein 5-like (Strongylocentrotus purpuratus) | Up | 1.76 | XP_786663.1 | 72 |
| S12 | comp75233_c0_seq13 | PAR6-like | partitioning defective 6 (Hemicentrotus pulcherrimus) | Down | −2.11 | BAF99001.1 | 77 |
| S13 | comp79698_c0_seq6 | EGFR/ RTK-like | Epidermal growth factor receptor (Apostichopus japonicas) | Up | 1.32 | AEY55412.1 | 97 |
| ERBB signaling pathway | |||||||
| A7 | comp76122_c1_seq21 | NCK2-like | Cytoplasmic protein NCK2 (Strongylocentrotus purpuratus) | Up | 3.62 | XP_784072.1 | 72 |
| A8 | comp76122_c1_seq7 | NCK2-like | Cytoplasmic protein NCK2 (Strongylocentrotus purpuratus) | Up | 2.72 | XP_784072.2 | 72 |
| A3 | comp79708_c0_seq1 | STAT5B-like | Signal transducer and activator of transcription 5B (Strongylocentrotus purpuratus) | Down | −3.81 | XP_003723422.1 | 70 |
| S13 | comp79698_c0_seq6 | EGFR/RTK-like | Epidermal growth factor receptor (Apostichopus japonicas) | Up | 1.32 | AEY55412.1 | 97 |
| MAPK signaling pathway | |||||||
| A9 | comp77146_c0_seq3 | MAP3K4-like | Mitogen-activated protein kinase kinase kinase 4 (Strongylocentrotus purpuratus) | Down | −2.23 | XP_784029.3 | 72 |
| A10 | comp78357_c1_seq8 | MAPK10-like | Mitogen-activated protein kinase 10 (Strongylocentrotus purpuratus) | Down | −4.43 | XP_786040.3 | 75 |
| S1 | comp79328_c1_seq13 | NFKB-like | Nuclear factor NF-κB p105 subunit (Apostichopus japonicas) | Up | 1.8 | AEP33644.1 | 68 |
| S13 | comp79698_c0_seq6 | EGFR/RTK-like | Epidermal growth factor receptor (Apostichopus japonicas) | Up | 1.32 | AEY55412.1 | 97 |
| S14 | comp80408_c0_seq17 | FLNA-like | Filamin-A (Strongylocentrotus purpuratus) | Up | 1.75 | XP_792145.3 | 74 |
A, represents disease-resistant gene; S, represents susceptibility gene. Log2 FC (fold change) indicates differential expression level of disease-resistant group (A) relative to the control group (K). “−”, indicates fold change of down-regulation.