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. 2015 Jul 20;16(7):16454–16468. doi: 10.3390/ijms160716454

Figure 7.

Figure 7

Mice were divided into 11 groups (n = 5 mice in each group) as follows. (A) Acute toxicity tests were conducted with the following groups of mice: the NS group (receiving normal saline via i.p. injection for 4 days), the AAI group (receiving 10 mg/kg AAI via i.p. injection (in warm saline) on day 4), and the baicalin (80 or 160 mg/kg) + AAI group (receiving baicalin daily for 3 days followed by a single i.p. injection of 10 mg/kg AAI on day 4); (B) Induction tests were conducted with the following groups of mice: The NS group (receiving normal saline via i.p. injection for 3 days), the baicalin group (receiving 80 mg/kg baicalin daily for 3 days), and the baicalin (80 mg/kg) + RES (50 mg/kg) group (receiving baicalin and RES daily for 3 days); (C) Pharmacokinetic assays were conducted with the following groups of mice: the NS group (receiving normal saline via i.p. injection for 3 days) with an i.p. injection of AAI (10 mg/kg) on day 4 and the baicalin group (80 or 160 mg/kg baicalin daily for 3 days) with an i.p. injection of AAI (10 mg/kg) on day 4.