Table 1.
Overall and stratified analyses on the association of rs11245007 genotypes with risk of breast cancer in Discovery cohort by multivariate logistic regression model
| Genotype | rs11245007 (C/T) | |||
|---|---|---|---|---|
| CC | CT | TT | CT + TT | |
| All subjects | ||||
| Cases (n = 1532) | 432 (28.20) | 738 (48.17) | 362 (23.63) | 1100 (71.80) |
| Controls (n = 1573) | 443 (28.16) | 768 (48.82) | 362 (23.01) | 1130 (71.84) |
| Crude OR (95 % CI) | 1.00 | 0.985 (0.834,1.164) | 1.025 (0.842, 1.249) | 0.998 (0.854, 1.167) |
| P | 0.863 | 0.802 | 0.982 | |
| Adjusted OR (95 % CI)a | 1.00 | 0.796 (0.638,0.992) | 0.952 (0.735,1.235) | 0.844 (0.687,1.037) |
| P | 0.0420 | 0.7124 | 0.1069 | |
| Parity <3b | ||||
| Cases (n = 1293) | 347 (26.84) | 636 (49.19) | 310 (23.98) | 946 (73.16) |
| Controls (n = 1122) | 314 (27.99) | 564 (50.27) | 244 (21.75) | 808 (72.01) |
| Adjusted OR (95 % CI)a | 1.00 | 0.962 (0.751,1.232) | 1.324 (0.987,1775) | 1.066 (0.846,1.345) |
| P | 0.7605 | 0.0607 | 0.5865 | |
| Parity ≥3b | ||||
| Cases (n = 188) | 67(35.64) | 81 (43.09) | 40 (21.28) | 121 (64.36) |
| Controls (n = 426) | 119 (27.93) | 194 (45.54) | 113 (26.53) | 307 (72.07) |
| Adjusted OR (95 % CI)a | 1.00 | 0.517 (0.304,0.879) | 0.469 (0.251,0.876) | 0.499 (0.307,0.813) |
| P | 0.0148 | 0.0175 | 0.0053 | |
| Family history of cancerc | ||||
| Cases (n = 474) | 126 (26.58) | 238 (50.21) | 110 (23.21) | 348 (73.42) |
| Controls (n = 169) | 31 (18.34) | 95 (56.21) | 43 (25.44) | 138 (81.66) |
| Adjusted OR (95 % CI)a | 1.00 | 0.530 (0.299,0.937) | 0.592 (0.304,1.151) | 0.548 (0.317,0.946) |
| P | 0.0289 | 0.1223 | 0.0308 | |
| No family history of cancerc | ||||
| Cases (n = 1057) | 306 (28.95) | 500 (47.30) | 251 (23.75) | 751 (71.05) |
| Controls (n = 1401) | 411 (29.34) | 672 (47.97) | 318 (22.70) | 990 (70.66) |
| Adjusted OR (95 % CI)a | 1.00 | 0.919 (0.723,1.166) | 1.130 (0.854,1.494) | 0.985 (0.788,1.230) |
| P | 0.4860 | 0.3933 | 0.8908 | |
Abbreviations: OR Odds ratios; CI confidence interval
aOR is adjusted for age, BMI, menarche age, parity, time of breast feeding, menopause, oral contraception, smoking status (ever/never), exercise, benign breast disease, and family history of cancer (first- and second-degree relatives)
bdue to missing values, n (total cases with parity data) < 1 532, n (total controls with parity data) < 1 573
cdue to missing values, n (total cases with family history of cancer data) < 1 532, n (total controls with family history of cancer data) < 1 573