Table 2.
Overall and stratified analyses on the association of rs11245007 genotypes with risk of breast cancer in Replication cohort by multivariate logistic regression model
| Genotype | rs11245007 (C/T) | |||
|---|---|---|---|---|
| CC | CT | TT | CT + TT | |
| All subjects | ||||
| Cases (n = 804) | 243 (30.22) | 364 (45.27) | 197 (24.50) | 561 (69.78) |
| Controls (n = 835) | 223 (26.71) | 392 (46.95) | 220 (26.35) | 612 (73.29) |
| Crude OR (95 % CI) | 1.00 | 0.852 (0.676,1.074) | 0.822 (0.631,1.071) | 0.841 (0.679,1.043) |
| P | 0.1748 | 0.1460 | 0.1148 | |
| Adjusted OR (95 % CI)a | 1.00 | 0.863 (0.668,1.115) | 0.789 (0.587,1.060) | 0.836 (0.659,1.061) |
| P | 0.2601 | 0.1158 | 0.1405 | |
| Parity <3b | ||||
| Cases (n = 468) | 129 (27.56) | 218 (46.58) | 121 (25.85) | 339 (72.44) |
| Controls (n = 505) | 137 (27.13) | 230 (45.54) | 138 (27.33) | 368 (72.87) |
| Adjusted OR (95 % CI)a | 1.00 | 1.059 (0.774,1.449) | 0.922 (0.646,1.318) | 1.008 (0.753,1.349) |
| P | 0.7209 | 0.6571 | 0.9590 | |
| Parity ≥3b | ||||
| Cases (n = 234) | 92 (39.32) | 93 (39.74) | 49 (20.94) | 142 (60.68) |
| Controls (n = 224) | 62 (27.68) | 107 (47.77) | 55 (24.55) | 162 (72.32) |
| Adjusted OR (95 % CI)a | 1.00 | 0.547 (0.343,0.872) | 0.579 (0.336,0.997) | 0.558 (0.363,0.857) |
| P | 0.0113 | 0.0492 | 0.0077 | |
| Family history of cancer | ||||
| Cases (n = 81) | 23 (28.40) | 33 (40.74) | 25 (30.86) | 58 (71.60) |
| Controls (n = 56) | 11 (19.64) | 27 (48.21) | 18 (32.14) | 45 (80.36) |
| Adjusted OR (95 % CI)a | 1.00 | 0.477 (0.179,1.270) | 0.390 (0.134,1.135) | 0.440 (0.178,1.089) |
| P | 0.1384 | 0.0839 | 0.0759 | |
| No family history of cancer | ||||
| Cases (n = 723) | 220 (30.43) | 331 (45.78) | 172 (23.79) | 503 (69.57) |
| Controls (n = 779) | 212 (27.21) | 365 (46.85) | 202 (25.93) | 567 (72.79) |
| Adjusted OR (95 % CI)a | 1.00 | 0.903 (0.691,1.181) | 0.836 (0.612,1.141) | 0.879 (0.685,1.128) |
| P | 0.4569 | 0.2585 | 0.3115 | |
Abbreviations: OR Odds ratios, CI confidence interval
aOR is adjusted for age, BMI, menarche age, parity, menopause, smoking status (ever/never), and family history of cancer (first- and second-degree relatives)
bdue to missing values, n (total cases with parity data) < 804, n (total controls with parity data) < 835