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. 2014 Nov 5;26(8):1806–1815. doi: 10.1681/ASN.2013121259

Figure 7.

Figure 7.

The sympathetic nervous system is activated in Mdk−/− mice. (A–C) Serum catecholamine (noradrenaline [A], dopamine [B], and adrenaline [C]) concentrations (n=5, each). (D) sBP change (ΔsBP) after intravenous administration of hexamethonium, a nicotinic acetylcholine receptor antagonist, is larger in Mdk−/− mice than in Mdk+/+ mice (n=4, each). P=0.08 (Mdk+/+ versus Mdk−/−). Data are presented as the mean±SEM. NAD, noradrenaline; DOPA, dopamine; AD, adrenaline; sBP, systolic BP.