Table 1.
Demographic and clinical characteristics of the individuals and patients enrolled in this study
| Demographic and Transplant Characteristics | Group | P Value | |||
|---|---|---|---|---|---|
| HV | TOL | STA | RC | ||
| Participants, n | 15 | 13 | 33 | 19 | |
| Donor type, n | |||||
| Cadaveric | — | 13 | 33 | 19 | |
| Living | — | 2 | — | — | |
| Recipient age, yr | 41 (37–45) | 55 (40–84) | 51 (18–73) | 51 (25–80) | 0.88 |
| Sex | 0.33 | ||||
| Women | 4 | 6 | 16 | 11 | |
| Men | 11 | 7 | 17 | 8 | |
| Time after transplantation, mo | — | 226 (114–347) | 129 (67–285) | 89 (26–241) | <0.001 |
| Creatinine level, μmol/L | — | 105 (63–216) | 107 (80–214) | 187 (109–957) | <0.001 |
| Proteinuria level, g/24 h | — | 0.2 (0–1.69) | 0.13 (0.03–0.39) | 1.6 (0.2–4.61) | <0.001 |
| HLA mismatch | — | 3 (0–5) | 3 (0–6) | 4 (0–6) | 0.23 |
| Cytomegalovirus infection | — | 6 (46.1) | 9 (27.3) | 4 (21.05) | 0.38 |
| Cancer | — | 5 (36.4) | 9 (31.0) | 3 (15.8) | 0.32 |
| Time of immunosuppression cessation, yr | — | 8 (2–15) | — | — | |
| Episode of acute rejection | — | 2 (15.4) | 5 (15.2) | 2 (10.5) | 0.88 |
| Reason for cessation | |||||
| Medical condition | — | 5 (38.5) | — | — | |
| Noncompliance | — | 8 (61.5) | — | — | |
| Chronic rejection | |||||
| C4d staining | — | — | — | 11 (57.9) | |
| Graft glomerulopathy | — | — | — | 17 (89.5) | |
| Donor-specific antibodies, n | — | 2 (15.4) | — | 4 (21.1) | |
| Immunosuppressive therapy | |||||
| Calcineurin inhibitor | — | 33 | 16 | ||
| Mycophenolate mofetil/mycophenolate sodium | — | 9 | 9 | ||
| Corticotherapy | — | 11 | 10 | ||
| Azathioprine | — | 8 | — | ||
Data are given as the median (range) or n (%), unless otherwise indicated.