Table 3.

Serum levels of autoantibodies versus different renal antigens, including podocyte proteins and implanted antigens

Autoantibodies and Proteinuria	LN (n=104)			SLE (n=84)				AR (n=50)				CTR (n=100)
	Median (mg/L)	Interquartile	>95° N (%)	Median (mg/L)	Interquartile	>95° N (%)	P versus LN	Median (mg/L)	Interquartile	>95° N (%)	P versus LN	Median (mg/L)	Interquartile	>95° N (%)	P versus LN
uProt24h T0	2.35	3.31	102	0.08	0.08	9		0.08	0.06	4		0.07	0.08	0.14
AENO IgG1 T0	0.36	0.46	17	0.38	0.34	0		0.03	0.01	0		0.44	0.37	0.796
AENO IgG2 T0	45.37	73.36	84 (81)	24.76	30.05	50 (69)	<0.001	3.67	8.42	8	<0.001	5.43	10.57	15.82	<0.001
AENO IgG3 T0	1.58	2.11	15	1.18	1.68	0	—	0.13	0.01	0	<0.001	2.05	2.14	3.80	—
AENO IgG4 T0	2.54	1.60	8	2.26	1.43	0	—	0.56	0.01	0	<0.001	2.51	2.14	4.30	—
ANX 1 IgG2T0	4.08	4.25	76 (73)	3.33	2.45	52 (62)	<0.001	2.08	0.90	9	<0.01	1.31	0.36	2.71	<0.001
H2A IgG1 T0	0.0126	0.06	16	0.0137	0.004	4	—	0.0105	0.004	1	<0.01	0.0136	0.004	0.02	—
H2A IgG2 T0	0.056	0.38	39	0.039	0.04	5	—	0.045	0.22	14	—	0.0387	0.053	0.15	<0.05
H2A IgG3 T0	0.012	0.06	47	0.012	0.05	38	—	0.011	0.040	20	—	0.012	0.001	0.013	—
H3 IgG1 T0	0.003	0.03	30	0.003	0.001	0	<0.01	0.003	0.046	15 (30)	—	0.003	0.001	0.004	—
H3 IgG2 T0	0.408	0.70	60 (58)	0.07	0.14	26 (31)	<0.001	0.192	0.42	27 (52)	<0.01	0.036	0.05	0.14	<0.001
H3 IgG3 T0	0.012	0.14	49 (47)	0.011	0.004	17 (20)	—	0.011	0.08	19 (38)	<0.05	0.011	0.004	0.012	<0.001
H4 IgG1 T0	0.016	0.08	19	0.017	0.004	5	—	0.015	0.004	7	—	0.017	0.003	0.02	—
H4 IgG2 T0	0.192	0.50	69	0.132	0.15	48	<0.001	0.250	0.45	31	—	0.054	0.08	0.115	<0.001
H4 IgG3 T0	0.007	0.001	10	0.007	0.001	4	<0.05	0.007	0.001	0	<0.05	0.008	0.001	0.008	—
DNA IgG2 T0	0.149	0.05	80 (77)	0.118	0.02	22 (26)	<0.001	0.133	0.04	30 (60)	<0.05	0.113	0.01	0.126	<0.001
DNA IgG3 T0	0.573	0.14	81 (78)	0.486	0.04	23 (27)	<0.001	0.528	0.10	31 (62)	<0.05	0.469	0.04	0.508	<0.001
C1Q IgG2 T0	0.068	0.02	60 (57)	0.056	0.01	16 (19)	<0.001	0.054	0.01	2	<0.001	0.047	0.01	0.064	<0.001
C1Q IgG4 T0	0.263	0.04	71 (68)	0.235	0.03	26 (31)	<0.001	0.233	0.02	8	<0.001	0.208	0.04	0.249	<0.001

Antibodies levels were determined for every isotypes with specific ELISAs and expressed as milligrams per liter.