Table 1.
MSCs in clinical trails for pulmonary diseases.
| Condition | Phase | Design | Number of participants | Cell origin | NCT ID |
|---|---|---|---|---|---|
| Adult ARDS | I | Open | 10 | bm-msc (allo) | NCT02215811 |
| I | Randomized, double-blind | 9 | bm-msc (allo) | NCT01775774 | |
| II | Randomized, placebo-controlled, double-blind | 60 | bm-msc (allo) | NCT02097641 | |
| I | Randomized, placebo-controlled, double-blind | 20 | at-msc (allo) | NCT01902082 | |
| Air leakage after lung resection | I/II | Open | 10 | msc N/S (auto) | NCT02045745 |
| Asthma | I/II | Open | 20 | cdm-uc (allo) | NCT02192736 |
| BPD | I‡(5) | Open | 9 | ucb-msc (allo) | NCT01297205 |
| I | Open | 12 | ucb-msc (allo) | NCT02381366 | |
| II | Randomized, placebo-controlled, double-blind | 70 | ucb-msc (allo) | NCT01828957 | |
| COPD | II‡(92) | Randomized, placebo-controlled, double-blind | 62 | bm-msc (allo) | NCT00683722 |
| IPF | I | Open | 18 | bm-msc (auto) | NCT01919827 |
| I‡ | Open | 8 | pla-msc (allo) | NCT01385644 | |
| II | Randomized, open | 60 | at-msc (auto) | NCT02135380 | |
| BOS after lung transplantation | I | Open | 9 | bm-msc (allo) | NCT02181712 |
| I | Open | 10 | msc N/S (allo) | NCT01175655 | |
| Pulmonary emphysema | I/II | Randomized, open | 30 | bm-msc (allo) | NCT01849159 |
Ongoing and completed interventional clinical trails listed on www.clinicaltrials.gov using mesenchymal stem or stromal cells to treat diseases of the lung.
‡Completed trials are marked with a diesis.
pla-msc, placenta-derived MSCs; bm-msc, bone marrow-derived MSCs; ucb-msc, umbilical cord blood-derived MSCs; at-msc, adipose tissue-derived MSCs; cdm-uc, conditioned media from umbilical cord-derived MSCs; msc N/S, source of cells not specified; allo, allogenic cells; auto, autologous cells.