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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Curr Addict Rep. 2015 Jan 28;2(1):76–90. doi: 10.1007/s40429-015-0046-y

Figure 1.

Figure 1

Depiction of the interplay among genetic and environmental factors that contribute to liability for alcohol use disorder (AUD), and the contribution of candidate endophenotypes and their associated genes and gene regions. Genes and gene regions that are associated with AUD candidate endophenotypes are highlighted here (references are documented in Table 2). These should be considered illustrative and not exhaustive. The “reaction surface” represents the probabilistic interplay among genetic and environmental factors in the development of risky alcohol use (i.e., consuming alcohol in quantities that put individuals at risk for alcohol-related harms) and AUD. Figure adapted from Gottesman & Gould [3] and used with permission.