Table I.

Spatial pattern of ipsilateral breast relapse (IBTR) in patients enrolled in randomized trials testing the effect of the whole breast radiotherapy [1]

Trial (time of primary treatment)	Median follow-up (range)	Recurrence number (total number of patients)	Pattern of IBTR
NSABP B-06 (1976-1984) [10]	39 (5-95) months	110 (1108)	86% within or close to the quadrant of the index cancer 14% more diffuse within the breast
Uppsala-Orebro (1981-1988) [11]	10 years	57 (381)	69% in the surgical field 3.6% in the cuticular scar 3.6% in the skin overlying the surgical field 23.6% in the breast parenchyma outside the field of surgery
Ontario Clinical Oncology Group (1984-1989) [12]	43 months	131 (837)	86% (83% with RT) at the site of primary surgery
Milan III (1987-1989) [13]	9 years	75 (579)	85% (84% with RT) in the scar area 15% (16% with RT) in other quadrants
SweBCG 91-RT (1991-1997) [14]	5 years	104 (1178)	90% in the same quadrant as the previous tumour 10% in other quadrants