Table II.
Spatial pattern of ipsilateral breast relapse (IBTR) in patients treated with breast conserving surgery plus whole breast radiotherapy [1]
| Authors, studies | Median follow-up (range) | Local recurrence rate (%) | Recurrence rate outside of the treated quadrant (%) | Recurrence rate in the second breast (%) |
|---|---|---|---|---|
| Retrospective clinical trials (BCS + EBRT) | ||||
| Kurtz et al. [15] | 11 (5-24 years) | 11 | 2 | 6 |
| Freedman et al. [26] | 5 years 10 years 15 years |
3 7 13 |
1 2 6 |
3 7 13 |
| Krauss et al. [27] | 5 years 10 years 15 years |
2 7 10 |
0.1 2 3 |
4 9 12 |
| Veronesi et al. [28] | 8.5 years | 6.8 | 1.4 | 5 |
| Prospective trials (BCS + EBRT) | ||||
| NSABP B-06 [18] | 39 (5-95) months | 2.7 | 0.7 | 9.4 |
| Uppsala-Orebro trial [11] | 10 years | 8.5 | 2.1 | 10.5 |
| Scottish trial [29] | 5.7 years | 5.8 | 1.4 | 1 |
| Milan III [28] | 9 years | 5.4 | 1.3 | 3.4 |
| NSABP B-21 [30] | 8 years | 9.3 | 2.3 | 5.4 |
| SweBCG 91-RT [14] | 61 (10-98) months | 4.4 | 1.1 | 3.4 |
| GBCSG trial [31] | 5.9 years | 4.2 | 1 | 2.1 |
| ABCSG study 8 [32] | 53.8 months | 0.5 | 0.1 | 0.5 |
BCS – breast conserving surgery, EBRT – external beam radiation therapy