Skip to main content
. Author manuscript; available in PMC: 2015 Jul 30.
Published in final edited form as: J Med Chem. 2013 Sep 5;56(18):7312–7323. doi: 10.1021/jm400770g

Scheme 2.

Scheme 2

a) (Boc)2O, Et3N, DMF, 130 °C, 1 h, 78%; b) Sn2Me6, Pd(PPh3)4, toluene, reflux, N2, 30 min, 81%; c) i) 2-(Diacetoxyiodo)thiophene, p-TsOH·H2O, MeCN, CH2Cl2, N2, rt, 1 h; ii) 12, MeCN, CH2Cl2, N2, rt, 18 h, 94%; d) KBr, MeCN, H2O, 60 °C-rt, 1 h, 71%