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. Author manuscript; available in PMC: 2015 Jul 30.
Published in final edited form as: J Med Chem. 2013 Sep 5;56(18):7312–7323. doi: 10.1021/jm400770g

Figure 8.

Figure 8

Patlak graphical analysis of the myocardial kinetics of [18F]1 kinetics in rhesus macaque monkeys under control conditions (n = 4) and following DMI block of cardiac NET at four different DMI dose levels. Patlak plots were highly linear in all cases (r2 > 0.99) and the Patlak slopes declined in a dose-dependent manner with increasing DMI doses.