Table 3.
Multivariable-adjusted* partial correlations for NAFLD as a dichotomous variable (LPR > 0.33 vs. LPR ≤ 0.33) or a continuous variable with vascular function measures.
| Vascular function measures | Model 1: MV* adjusted |
Model 2: Model 1 + BMI adjusted |
Model 3: Model 2 + VAT adjusted |
||||
|---|---|---|---|---|---|---|---|
| N | r | P-Value | r | P-Value | r | P-Value | |
| Dichotomous fatty liver | |||||||
| Brachial artery measures† | |||||||
| Flow-mediated dilation (%) | 2061 | −0.02 | 0.30 | −0.01 | 0.61 | −0.01 | 0.66 |
| Peripheral Arterial Tonometry measures |
|||||||
| Peripheral arterial tone ratio (unitless) | 1393 | −0.12 | <0.0001 | −0.09 | 0.0005 | −0.08 | 0.004 |
| Arterial tonometry measures | |||||||
| −1,000/Carotid-femoral pulse wave velocity (ms/mm) † |
2284 | 0.05 | 0.03 | 0.03 | 0.23 | 0.007 | 0.73 |
| −1,000/Carotid-femoral pulse wave velocity (ms/mm) |
2284 | 0.02 | 0.29 | 0.01 | 0.55 | −0.004 | 0.85 |
| Mean arterial pressure (mm Hg) | 2284 | 0.06 | 0.005 | 0.03 | 0.20 | 0.02 | 0.26 |
| Mean arterial pressure (mm Hg) ‡ | 2284 | 0.05 | 0.03 | 0.02 | 0.37 | 0.02 | 0.28 |
| Continuous fatty liver | |||||||
| Brachial artery measures† | |||||||
| Flow-mediated dilation (%) | 2061 | −0.04 | 0.06 | −0.03 | 0.15 | −0.03 | 0.17 |
| Peripheral Arterial Tonometry measures |
|||||||
| Peripheral arterial tone ratio (unitless) |
1393 | −0.13 | <0.0001 | −0.10 | 0.0001 | −0.08 | 0.002 |
| Arterial tonometry measures | |||||||
| −1,000/Carotid-femoral pulse wave velocity (ms/mm) † |
2284 | 0.03 | 0.12 | 0.01 | 0.52 | −0.009 | 0.66 |
| −1,000/Carotid-femoral pulse wave velocity (ms/mm) |
2284 | 0.02 | 0.31 | 0.01 | 0.57 | −0.01 | 0.68 |
| Mean arterial pressure (mm Hg) | 2284 | 0.02 | 0.28 | −0.01 | 0.68 | −0.01 | 0.51 |
| Mean arterial pressure (mm Hg) ‡ | 2284 | 0.01 | 0.61 | −0.02 | 0.47 | −0.01 | 0.60 |
NAFLD, Non-alcoholic fatty liver disease; BMI, body mass index; VAT, visceral adipose tissue.
Multivariable models adjusted for age, sex, cohort, smoking, mean arterial pressure (not included in models with mean arterial pressure or CFPWV as dependent variable, unless noted), heart rate, walk test (before, only for brachial measures†), total/high density lipoprotein cholesterol, triglycerides, fasting glucose level, menopause, hormone replacement therapy, diabetes, hypertension treatment and lipid lowering treatment.
not adjusted on mean arterial pressure;
additional adjusted on carotid femoral pulse wave velocity.