Skip to main content
. Author manuscript; available in PMC: 2015 Jul 30.
Published in final edited form as: Alcohol Clin Exp Res. 2011 Jun 20;36(1):43–54. doi: 10.1111/j.1530-0277.2011.01579.x

Fig. 5.

Fig. 5

Mean (± S.E.M.) responses per 10-min blocks on the EtOH lever by P rats given saline (n = 4–5/time point), or 0.1, 0.3, or 1.0 mg/kg nicotine (n = 7–9/group/time point) immediately or 4-hr prior to the first relapse session. Upper Panel: asterisk (*) indicates that rats administered saline or 0.1 mg/kg 4-hr prior to test session responded significantly (p < 0.05) more on the EtOH lever during initial 0–20-min and final 10-min of relapse testing compared to rats injected with 0.1 mg/kg nicotine immediately prior to the test session. Middle Panel: asterisk (*) indicates that rats administered 0.3 mg/kg nicotine immediately responded significantly (p < 0.05) less on the EtOH lever during 0–20-min of relapse testing compared to saline, and rats administered 0.3 mg/kg nicotine 4-hr prior to relapse testing displayed an increase in EtOH responding during the 3rd and 6th 10-min block compared to saline. Lower Panel: asterisk (*) indicates that rats administered 1.0 mg/kg nicotine immediately responded significantly (p < 0.05) less on the EtOH lever during 0–20-min of relapse testing compared to saline, and rats administered 1.0 mg/kg nicotine 4-hr prior to relapse testing displayed an increase in EtOH lever responses during 1st, 2nd, and 6th 10-min block compared to saline.