Table 2.

Heterogeneity of Tissue Macrophages in Mice

Lymphoid tissue macrophages
Spleen		Lymph node	Bone marrow	Thymus
Phenotype and Localization	Red pulp MØ -Entire red pulp -F4/80hiCD11bloCD169loMHCIIlo CD163+CD68+CD115+CD172a+	Subcapsular sinus MØ -Lining subcapsular sinus -F4/80loCD11b+CD169+CD11clo MARCO+	Bone marrow CD169+ MØ -Distributed throughout the marrow but enriched around the hematopoietic stem cell niche F4/80+CD11bloCD169+CD11clo CD68+CX3CR1−CD115+	Subcapsular MØ -MHCII+F4/80+Mac-2−FcγRII+FcγRIII+
	Marginal zone MØ -Outer layer of marginal zone sinus -F4/80−SIGN-R1+MARCO+	Medullar MØ -Lining medullar sinus -F4/80hiCD11b+CD169+CD11clo		Cortex MØ -MHCII−F4/80+Mac-2+FcγRII+FcγRIII+
	Marginal zone metallophilic MØ -Inner layer of marginal zone sinus -F4/80−CD169+	CD11chiCD169+ MØ -Boundary between the sinus and the T cell zone or B cell follicle -MHCII+F4/80+CD169+CD11chiCD8+		Cortico-medullary MØ -MHCII+F4/80+Mac-2+ FcγRIIhiFcγRIIIhi
	Tingible body MØ -Germinal center -F4/80−CD11b−CD68+MFG-E8+	Tingible body MØ -Germinal center -F4/80−CD11b−CD68+MFG-E8+		Medulla MØ -Germinal center -MHCIIhiF4/80+Mac-2+ FcγRII+FcγRIII+
References	Lloyd et al., 2008 Kohyama et al., 2009 Miyake et al., 2007 You et al., 2011 Hanayama et al., 2004 Rabinowitz et al., 1991	Phan et al., 2009 Asano et al., 2011	Chow et al., 2011 Crocker and Gordon, 1986	Soga et al., 1997

Non-lymphoid tissue macrophages
Liver		Lung	Gut	Skin	Kidney
Phenotype and Localization	Kupffer cell -In the liver sinusoid -F4/80hiCD11bloCD169+ CD68+Mac-2+	Alveolar MØ -Alveolar airspace -F4/80+CD11bloCD169+ CD11chiCD68+SiglecF+ MARCO+Mac-2+	Lamina propria MØ -Intestinal lamina propria -MHCII+F4/80+CD11b+ CD11c+CD103−CD115+ CX3CR1+CD172a+	Dermal MØ -F4/80+CD11b+CD11clo mMGL+CD206+MHCIIlo In deep dermis, MØ can express CD169+	Kidney MØ -F4/80+CD11bloCD103− CX3CR1+CD172a+
		Interstitial MØ -Alveolar interstitium -CD11c−F4/80+CD68+ MHCII+	Serosal DC or MØ -Intestinal muscular layer and serosa -MHCIIhiF4/80+CD11b+ CD169+CD11cloCX3CR1+ CD103−CD115+
References	Flotte et al., 1983 Kinoshita et al., 2010 Crocker and Gordon, 1989	Flotte et al., 1983 Tateno et al., 2007 Ducreux et al., 2009 Palecanda et al., 1999 Bedoret et al., 2009 Lagranderie et al., 2003	Bogunovic et al., 2009 Flores-Langarica et al., 2005	Dupasquier et al., 2004 Dupasquier et al., 2006	Our unpublished data

This table describes the name, localization, and phenotype of macrophage populations that reside in the spleen (Hanayama et al., 2004; Kohyama et al., 2009; Lloyd et al., 2008; Miyake et al., 2007; Rabinowitz and Gordon, 1991; You et al., 2011), lymph nodes (Phan et al., 2009); (Asano et al., 2011), bone marrow (Chow et al., 2011; Crocker and Gordon, 1986), thymus (Soga et al., 1997), liver (Crocker and Gordon, 1989; Flotte et al., 1983; Kohyama et al., 2009), lungs (Bedoret et al., 2009; Ducreux et al., 2009; Flotte et al., 1983; Lagranderie et al., 2003; Palecanda et al., 1999; Tateno et al., 2007), gut (Bogunovic et al., 2009; Flores-Langarica et al., 2005), and skin (Dupasquier et al., 2004; Dupasquier et al., 2006).