Fig. 6.
In vivo brain imaging of exosome delivered rhodamine 123 in Tg (fli1:GFP) embryonic zebrafish. Rhodamine 123 (red) retained within vessels (green) after the injected formulations without exosome (a) and with exosomes isolated from (b) neuroectodermal tumor PFSK-1, (c) glioblastoma A-172, and (d) glioblastoma-astrocytoma U-87 MG. Rhodamine 123 (red) crossed out of vessels (green) after the injected formulation with exosomes isolated from (e) brain endothelial bEND.3 cells.