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. 2015 Jul 30;10(7):e0134299. doi: 10.1371/journal.pone.0134299

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© 2015 Hu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 8 — (A-B) Enhanced expression of p21b ^CIP1/WAF1 (cdkn1a) in ddb1 ^m863 homozygous embryos in the proliferation regions of the optic tectum, compared to wild type siblings at 36 hpf. (C-D) At 48 hpf, p21b ^CIP1/WAF1 expression was strongly elevated in proliferation regions of the optic tectum, cerebellum, telencephalon, retina, branchial arches and pectoral fin bud in ddb1 ^m863 mutants compared to wild type siblings. In contrast, expression of p21b ^CIP1/WAF1 in ventral hindbrain nuclei (arrow heads in B, D) was unaltered in ddb1 ^m863 mutants. All views are lateral except for inserts (dorsal views). Abbreviations used: Cce, cerebellum; H, hypothalamus; L, lens; pfb, pectal fin bud; ret, retina; tel, telencephalon; TeO, tectum opticum. Anterior towards the left. Scale bar: 100 μm.