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. 2015 Jul 30;10(7):e0134297. doi: 10.1371/journal.pone.0134297

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© 2015 Penedos et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — (A) Hop1 and Mek1-HA chromosome association during dmc1Δ meiosis at 23°C in a HOP1, hop1-S298A, or hop1-T318A background. (B) and (C) Effects of hop1-S298A or hop1-T318A on Hop1 chromosome association during DMC1 or dmc1Δ meiosis. Fraction of cells exhibiting 10 or more Hop1 foci was scored. (D) and (E) Effects of hop1-S298A or hop1-T318A on Mek1-HA chromosome association during DMC1 or dmc1Δ meiosis. Fraction of cells exhibiting 10 or more Mek1-HA foci was scored. (F) and (G) Effects of hop1-S298A and hop1-T318A on Hop1-Mek1 co-localization during DMC1 and dmc1Δ meiosis. Fraction of nuclei where more than 80% of Mek1-HA foci co-localized with Hop1 foci was scored. (B-G) Errors were calculated from the 95% confidence interval of a binomial distribution. (H) and (I) Effects of hop1-S298A on Hop1-Mek1 interaction on chromosomes. Nuclear spreads of HOP1 dmc1Δ and hop1-S298A dmc1Δ were prepared from samples taken at 6 hours after induction of synchronous meiosis at 23°C. The spreads were stained with DAPI and the antibodies against Hop1 and HA (for detection of Mek1-HA).