Table 1. Known genotoxic compounds identified with the DDR-Act-Fp reporter system amongst 1,280 pharmacologically compounds of the LOPAC library.

Results are expressed as percentage of the fluorescence intensity measured in cells treated with 10μM Etoposide. ID number, compound name and putative mode of action are indicated.

Fluorescence (% of pos. control)	ID	Compound name	Mode of action
100	Pos. control	Etoposide	Topoisomerase II inhibitor
112	-	Nutlin-3	Mdm2-p53 interaction inhibitor
110	M6545	Mitoxantrone	DNA synthesis inhibitor
108	I1656	Idarubicin	Antineoplastic
104	A9809	Amsacrine	Topoisomerase II inhibitor
91	E1383	Etoposide	Topoisomerase II inhibitor
83	T2705	Topotecan	Topoisomerase I inhibitor
82	A8598	Ancitabine hydrochloride	Antineoplastic
80	C6645	Cytosine-1-ß-arabinofuranoside	DNA synthesis inhibitor
78	A6770	Methotrexate hydrate	Folic acid antagonist
76	A1784	Aminopterin	Dihydrofolate reductase inhibitor
73	G6423	Gemcitabine	Antineoplastic
64	F6627	5-Fluorouracil	Thymidilate synthetase inhibitor
63	F8791	5-Fluoro-5’-deoxyuridine	DNA synthesis inhibitor
59	E3380	Ellipticine	Topoisomerase II inhibitor
58	C9510	Pyrocatechol	Carcinogen