. 2015 Jun 18;106(7):857–866. doi: 10.1111/cas.12684

Table 3.

Relationship between vasculogenic mimicry (VM), histone deacetylase 3 (HDAC3), and clinicopathological data of patients with glioma

Parameters	Cases	VM		χ²	P-value	HDAC3			χ²	P-value
		Positive	Negative			High		Low
		Positive	Negative			+++	++	–/+
Gender
Male	61	16	45	0.044^†	0.834	17	30	14	1.677^†	0.432
Female	41	10	31	0.044^†	0.834	7	23	11	1.677^†	0.432
Age, years
<40	45	11	34	0.982^†	0.610	10	23	12	0.425^‡	0.990
≥40 to <60	32	10	22			10	16	6
≥60	25	5	20			4	14	7
Tumor size, cm
<5	53	14	39	0.824^†	0.943	15	24	14	2.549^†	0.280
≥5	49	12	37	0.824^†	0.943	9	29	11	2.549^†	0.280
Grade, WHO
I	6	0	6	7.502^‡	0.048^$	0	2	4	33.390^‡	0.000^$
II	40	6	34			7	19	14
III	23	7	16			6	13	4
IV	33	13	20			11	19	3
KPS
<65	45	12	33	0.059^†	0.810	6	16	23	3.018^†	0.221
≥65	57	14	43	0.059^†	0.810	13	24	20	3.018^†	0.221
HDAC3
Low −/+	43	6	37	6.315^†	0.043^$	–	–	–		–
High ++	40	12	28			–	–	–
High +++	19	8	11			–	–	–
VM
Positive	23	–	–		–	8	12	6	6.203^†	0.045^$
Negative	76	–	–	11	–	28	37		6.203^†	0.045^$

†Statistical analyses were carried out using the χ²-test (asymptotic significance, two-sided). ‡Fisher’s exact test (two-sided); ^$P < 0.05 was considered significant. −/+, <10% negative or weakly positive HDAC3 expression; ++, 20–50% strongly positive HDAC3 expression; +++, >50% very strongly positive HDAC3 expression; KPS, preoperative Karnofsky performance scores.