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. 2015 May 26;106(7):875–882. doi: 10.1111/cas.12686

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig 5 — Antitumor activity of imatinib (Imt) in vivo. (a) Weight of AXT cell-derived s.c. tumors in mice treated with adriamycin (ADR), imatinib, or both. (b) Proportion of Ki67⁺ cells determined by immunohistochemical (IHC) analysis of tumors from mice treated as in (a). Left, representative images of Ki67 staining. Right, quantification of Ki67 positivity. (c) Quantitative analysis for lung metastatic lesions in mice treated as in (a). Left, representative images of lung metastatic lesions. Right, quantitative data of metastatic area presented as box-and-whisker plots. $P < 0.05. NS, not significant.