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. 2015 May 29;106(7):921–928. doi: 10.1111/cas.12692

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fig 1 — Function of a fully humanized monoclonal antibody, MT95-4, in vitro. (a) Evaluation of the specificity of MT95-4 by western blotting analysis using cell lysates from HT1080 cells. (b) Effects of MT95-4 on the aminopeptidase activity of HT1080 cells. The levels of AMC released from Ala-MCA were measured. Data represent the mean (± SEM) of triplicate samples. $P < 0.05 versus the control. NS, not significant. (c) Effects of MT95-4 on the invasion of HT1080 cells in a Matrigel invasion assay. Data represent the mean (± SEM) of five wells. $$$P < 0.001 versus the control.